Haplotype Frequencies

A-B-DRB1 224 Haplotype Frequencies

EM Haplotype Frequency Estimates by Race/Ethnicity

Frequencies of HLA-A, B, DRB1 haplotypes were estimated by race/ethnicity from a subset of donors in the NMDP registry. Characteristics of this subset are identified in the table below.

   African American / Black Asian / Pacific Islander Hispanic White Total
Volunteers available (N = 412,861) (N = 359,423) (N = 449,844) (N = 2,361,208) (N = 3,583,336)
Level of DRB1 Typing
None 37,503 (9%) 40,601 (11%) 47,771 (11%) 773,172 (33%) 899,047 (25%)
Serology 1,600 (<1%) 2,853 (<1%) 2,466 (<1%) 68,379 (3%) 75,298 (2%)
Low Resolution DNA 53,015 (13%) 44,561 (12%) 47,518 (11%) 171,538 (7%) 316,632 (9%)
Intermediate Resolution DNA 283,053 (69%) 251,433 (70%) 322,175 (72%) 1,196,807 (51%) 2,053,468 (57%)
Allele(s) determined 37,690 (9%) 19,975 (6%) 29,914 (7%) 151,312 (6%) 238,891 (7%)

Estimated haplotype frequencies are found in the files listed below. Each file format lists the same set of HLA-A, B, and DRB1 allele combinations. Only haplotypes with an observed frequency of at least 1 x 10-6 in at least one of the identified race/ethnic groups have been included.

EM Haplotype Frequency