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  • A-B-DRB1 224 Haplotype Frequencies
  • High-Resolution HLA Alleles and Haplotypes in the US Population
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  • High-Resolution HLA Alleles and Haplotypes in the US Population
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High-Resolution HLA Alleles and Haplotypes in the US Population

The high-resolution frequencies have been updated as of December 2007, and represent an erratum to the original published frequencies. Please download the new frequency tables and updated manuscript tables and figures.

For complete details on this study, read the article:

Maiers, M., Gragert, L., Klitz, W. High resolution HLA alleles and haplotypes in the US population. Human Immunology (2007) 68, 779-788.

Table 1 - Definition of alleles identical over antigen binding domain (PDF)

Table 2 - Total chromosome counts per allele and haplotype category (PDF)

Table 3 - Number of distinct alleles observed (PDF)

Table 4 - Hardy-Weinberg test results (PDF)

Table 5 - Haplotype sampling statistics (PDF)

Table 6 - Top 10 A-B-DRB1 frequencies compared by race/ethnic group (PDF)

Figure 1 - Frequency distribution of Top 25 A-B-DRB1 haploytypes (PDF)

Figure 2 - Haplotype frequency comparisons with full registry samples (PDF)


High Resolution HLA Alleles and Haplotypes in the US Population


 

HLA-A PDF XLS
HLA-B  PDF XLS  
HLA-DRB1  PDF XLS
HLA-C PDF XLS  
HLA-DQB1 PDF XLS
       
HLA-A-B PDF XLS  
HLA-A-B-DRB1  PDF XLS
HLA-A-B-DRB1-DQB1 PDF XLS
HLA-A-C-B PDF XLS
HLA-A-C-B-DRB1 PDF XLS
HLA-A-C-B-DRB1-DQB1  PDF XLS
HLA-B-DRB1 PDF XLS
HLA-C-B  PDF XLS
HLA-C-B-DRB1-DQB1 PDF XLS
HLA-DRB1-DQB1  PDF XLS

Human Immunology Manuscript Frequencies - 2006
Note: These frequencies are deprecated, but match the sample counts from the published September 2007 Human Immunology journal article. Individuals carrying HLA alleles (A*0201g and A*2402g) were systematically excluded from a subset of our population (roughly half of the minority groups: AFA, API, HIS) due to a technical issue with allele ambiguities and our failure to characterize these two allele groups as high-resolution. 
 
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